1. | POLYGONUM ARENASTRUM: PHARMACOGNOSTICS, PHYTOCHEMICALS, AND ANTHELMINTIC PHYSICIDS |
| Ravichandran S1*, Bhavani J2, Manikgantan E. M |
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Article Type:Research Article/
Abstract
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Pages (1-5) |
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There are a number of people in India who use Polygonum arenastrum as an anthelmintic herb. The leaves of Polygonum arenastrum were studied pharmacognostically, phytochemically, and pharmacologically. Water soluble extractive value and alcohol soluble extractive value were determined, as well as physicochemical constants such as moisture content, ash values and extractive values. It was determined that the extract obtained from successive solvent extractions could contain a number of phytochemical compounds after a preliminary phytochemical analysis was carried out. Soxhlet apparatus was used to extract leaves of Polygonum arenastrum with solvents benzene, acetone, ethanol, and water. In order to determine the anthelmintic potential of the extract, Indian earthworms were used in the study. Polygonum arenastrum ethanol extract has been found to possess significant activity when compared to other ethanol extracts
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2. | TRANSDERMAL PATCH INCORPORATING HERBAL BIOACTIVE INGREDIENTS: SYNTHESIS, OPTIMISATION & EVALUATION |
| Sode. Harathi*, Boda Veeru Naik, Dr. Purushothaman M |
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Article Type:Research Article/
Abstract
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Pages (10-18) |
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Drug delivery systems (DDS) are formulations that allow the introduction of therapeutic substances into the body and improve their efficacy and safety by regulating the rate, time, and location of drug release. The term "drug carrier" refers to any substrate used in the delivery of drugs in order to improve their selectivity, effectiveness and safety. Formulation were evaluated for its Physicochemical characteristic such as particle size, Polydispersity index, zeta potential and also evaluated for entrapment efficiency, Drug content, In vitro drug release study
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3. | PSORALEA PINNTA ACTIVE COMPONENTS SEPARATED,
IDENTIFIED AND QUANTIFIED USING HPLC-UV & HPLC- MS |
| Aetukuri Lavanya*, Rajitha S, Purushothaman M |
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Article Type:Research Article/
Abstract
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Pages (19-24) |
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Medical Science advancements have made it possible to develop a large number of drugs. A qualitative analysis identifies the
presence or absence of certain components in a sample in order to provide us with information about the sample's nature. The
potential pharmacological properties of many plants are constantly being investigated (such as inflammatory, hypotensive,
hypoglycaemic, amoebicidals, antifertility, cytotoxic and antibiotics). Psoralea corylifolia belongs to the family Fabaceae
which is commonly known as blue pea. There are 130 species in the Fabaceae family's Psoralea genus, most of which are
found in South Africa, North and South America, and Australia. Phytochemical evaluation is used to determine the nature of
Phytoconstituents present in the plant by using suitable chemical tests as per standard procedure. Solvent mixture was selected
on the basis of the phytoconstituents present in each extract. The separation of constituents in the extract of Psoralea
corylifolia was performed by HPLC-UV and MS in negative ion mode. HPTLC technique is helpful in order to check the
identity, purity and standardize the quantity of active principles present in the herbal extract. Powdered drugs are generally
identified by their physiochemical parameters. Physiochemical property characterization has gained strength in the
pharmaceutical industry and has become a standard procedure. Loss on drying, total ash, soluble and insoluble ash, extractive
values are reliable aids for detecting adulteration. The HPTLC chromatogram for Psoralea corylifolia (HAEPC) showed
significant separation of three phytoconstituents with Rf values ranging from 0. 43 to 0.83. HPTLC studies indicate the plant
extract contains three phytoconstituents. We studied macroscopy and physicochemical parameters to identify adulterants.
Carbohydrates, Proteins, Steroids, Terpenoids, and Flavonoids were detected in the crude drug and formulated lozenges. This
will help in preventing variation in the quality of the drug because the physicochemical constants were determined. P.
corylifolia contains bavachin, bakuchiol, and psoralen, all of which are commercially available
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4. | PRINCIPAL COMPONENT ANALYSIS AND CHROMATOGRAPHIC
FINGERPRINTING OF AZIMA TETRACANTA SAMPLE |
| Gunti Jyostna*, Rajitha S |
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Article Type:Review Article/
Abstract
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Pages (25-33) |
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Many plant species are used by traditional healers and indigenous medical systems (including Ayurveda, Siddha, and Unani) to
treat a variety of human and animal illnesses. Studies on the plant's phytochemistry found that it included substances such
friedelin, euphanol, gallic acid, genstisic acid, cinnamate, ferulic acid, azimine, azcarpine, and carpaine. Standard
phytochemical tests, gas chromatography-mass spectrometry (GC-MS), high-performance liquid chromatography, liquid
chromatography–MS, and other chromatographic techniques, as well as spectral analyses such as nuclear magnetic resonance
and infrared, have been utilized by a variety of researchers in order to identify chemicals or phytochemical groups that are
present in different parts of the plant. Ash values, extractive values, loss on drying and foreign organic matters were
determined as per the standard WHO guidelines which is very much useful in the determination of quality and purity of the
crude drugs. Ethanolic extract of Azima tetracanta is subjected to qualitative chemical analysis. The extract was analysed using
a liquid chromatography (Shimadzu, Japan). Thin Layer Chromatography of the Ethanolic extract of Azima tetracanta was
performed and Rf values were determined. Ethanolic extract of Azima tetracanta was subjected to in vitro antioxidant studies.
Ethanolic extract of A. tetracantha leaves exhibited a concentration dependant free radical scavenging property as observed
from hydrogen peroxide assay. Antioxidant property of A. tetracantha may be one of the reasons for its use as a rejuvenating
drug in the traditional medicinal practices
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5. | GREEN SYNTHESIS OF ZINC-OXIDE NANOPARTICLES USING
ETHANOLIC EXTRACT OF PELTOPHORUM PTEROCARPUM
LEAVES |
| Nunavath Vijayalakshmi*, Rajitha S, Purushothaman M |
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Article Type:Review Article/
Abstract
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Pages (34-41) |
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ZnO is a transparent electrode material that has been employed in emerging applications of transparent electrodes in liquid
crystal displays, as well as in heat-absorbing or energy-saving windows. The physical, optical and electrical properties of zinc
oxide are unique among transition metal oxides. Pharmaceuticals, electronics, consumer goods, optical and electrical devices,
and environmental remediation are among the many fields in which they can be used because of their unique properties. ZnO is
also being used in electronics for thin-film transistors and light-emitting diodes
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6. | IN VITRO ANTIBACTERIAL CHARCTERISATION OF NANOGEL:
AZIMA TETRACANTHA |
| Dara Venkata Raja Rajeswari*, Swathi A, Purushothaman M |
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Article Type:Review Article/
Abstract
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Pages (6-9) |
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The plant A. tetracantha is shown to contain a variety of phytochemicals which are distributed in various parts of the plant.
Nutritional composition of leaves of A. tetracantha Potassium and manganese were detected in highest quantity among major
and minor elements. Easy to manufactures and chief in cost. Nanogel was first introduced to define cross-linked bifunctional
networks a polyion and a non-ionic polymer for delivery of polynucleotides and poly ethylene glycol (PEG). Nanogels are very
promising in drug delivery applications due to their high loading capacity
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7. | BIOPROSPECTING FOR ANTI-STREPTOCOCCUS MUTANS: THE
ACTIVITY OF SESBANIA GRANDIFLORA LEAVES EXTRACT
COMPARABLE TO AZITHROMYCIN |
| Kanakam Bhavya*, Purushothaman M, Sorakayal Nayomi, Eluri Thiranya, Bandi Vasavi. |
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Article Type:Review Article/
Abstract
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Pages (42-44) |
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To look for an herbal substance that can prevent the plaque-producing bacteria Streptococcus mutans. Methods: Using hydro
alcohol, Sesbania grandiflora leaves and Costus speciosus rhizomes were extracted (70:30). They were then tested in vitro on
Mueller-Hinton media against Streptococcus mutans at a concentration of 10% (w/v). As a positive control, azithromycin (20
mg disc) was used. Results: With inhibited zone widths of 17.5 and 13.5 mm, respectively, Sesbania grandiflora (S.
grandiflora) leaves and Costus speciosus rhizome extracts demonstrated the most effective activity of the examined samples. S.
grandiflora's activity (diameter = 18.0 mm) was comparable to that of azithromycin. The flower of the S. grandiflora plant
holds promise for use as an anti-plaque toothpaste and mouthwash solution active ingredient
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