Phytopharmacy Research

Ormacarpum cochichinase is a shrub Which is extremely efficacious in mending bone fractures,but at present it's use is known only to handful of villagers in the tropical dry evergreen forest areas of Tamil Nadu for healing bone fractures . Other than bone mending this plant have some more pharmacological potentials like anti-inflammatory, anti-arthritic, muscitocidal, antimicrobial and so on. This study aims on phytochemical analysis and the study of anti-inflammatory potential. The phytochemical analysis was done by various chemical tests and the anti-inflammatory potential was studied by using egg albumin denaturation assay. Further research works should be carried out for the better understanding of this plant and it`s pharmacological potential.

Cancer is one of the most complicated diseases with various treatments, which each has its special side effects. So, pharmaceutical companies are intended to develop new drugs with minimum side effects. Objectives: The current study aimed to investigate the cytotoxicity effects and the redox potential of alcoholic extract of Lavandula Stoechas leaf on liver carcinoma cell line (HepG2). Methods: Lavandula Stoechas leaves were collected from Bhopal (India), and the alcoholic extract of the plant leaves was prepared. HepG2 cells were cultured in DMEM medium and treated with 50, 100, 200, 400, and 600 µg/mL of the extract. The cytotoxicity effect of the extract was evaluated using the MTT and the Neutral Red assays. Redox potential in HepG2 cells was assessed using NO, catalase, and GSH tests. The expression of Bax and bcl-2 genes in HepG2 cells was evaluated for apoptosis analysis. Results: The results showed that the extract could significantly (P < 0.001) reduce the viability of HepG2 cells. Also, the extract significantly increased the amount of released NO, catalase activity, and GSH concentration. RT-PCR results showed that Lavandula Stoechas leaf extract significantly change the expression of bax and bcl-2. Conclusions: The results showed that the leaves of the Lavandula Stoechas plant contain compounds with cytotoxicity properties, so it can be considered as a potent candidate for liver cancer treatment

This study evaluates the impact of post-harvest drying methods on the quality and antioxidant activity of coriander, a spice known for its medicinal properties and high quercetin content. Coriander's moisture content at harvest necessitates effective drying techniques to minimize microbial attack and maintain quality. The study compares the effects of shade drying, sun drying, and hot air oven drying on coriander's chemical constituents and antioxidant properties. Preliminary phytochemica l screening of methanol extracts from various parts of coriander revealed the presence of polyphenols, flavonols, carbohydrates, proteins, and glycosides, regardless of the drying method. Total phenol and flavonoid contents were highest in shade -dried stems and lowest in hot air oven-dried roots. The DPPH free radical scavenging method showed that shade-dried parts exhibited the best antioxidant activity, followed by sun-dried and hot air oven-dried parts. The findings indicate that shade drying is superior in preserving phenolic and flavonoid contents and enhancing antioxidant activity. This suggests that optimizing post-harvest drying methods, particularly shade drying, is crucial for improving the export quality of coriander. Further studies using advanced analytical techniques like HPLC and GC are recommended to quantify individual chemical constituents and their distribution in different parts of the coriander plant

The alkaloid piperine, found in black pepper, exhibits significant pharmacological properties, but is insoluble and unstable in water, making it challenging to administer topically. The purpose of this study was to develop and evaluate piperine-loaded emulgels using polymers in order to improve their topical delivery and therapeutic effectiveness. To determine whether different gelling agents impact the formulation characteristics and drug release profile of emulgels, Carbopol 940 and Hydroxypropyl Methylcellulose (HPMC) were used. Piperine was found to be compatible with the selected polymers and excipients in preformulation studies. Physical properties of the prepared emulgels, such as viscosity, spreadability, pH, and drug content uniformity, were evaluated to ensure they met acceptable standards. FTIR (Fourier Transform Infrared Spectroscopy) analyses confirmed the stability of piperine within the emulgel matrixes and the absence of significant interactions between the drug and polymer. Based on in vitro skin permeation studies, the optimized emulgel formulation provided enhanced transdermal delivery of piperine. The findings of this study demonstrate that the choice of polymer significantly impacts the physical properties and drug release profiles of piperine emulgels

Aconitum ferrox is a medicinal plant native to India that belongs to the Ranunculaceae family. A. Ferrox is reported to have a variety of medicinal properties. Since ancient times, this plant has employed several formulations in India's traditional treatment system, Ayurveda. It has been used to treat urinary infections, diarrhea, and inflammation in patients. It's also been utilized to promote hepatoprotective activity and as an expectorant. Alkaloids, carbohydrates, proteins and amino acids, saponins, glycosides, quinones, flavonoids, terpenoids, and other compounds have been discovered in various plant portions, according to chemical investigations. The therapeutic characteristics of A. Ferrox, as well as their phytochemistry and pharmacognosy, are discussed in this study. Scientific data on the plant was gathered from various sources, including electronic sources (Google scholar, Pubmed) and some old Ayurvedic and ethnopharmacology textbooks. The research also includes a review of the literature on A. ferrox, as well as the most relevant pharmacological and other results on this drug. This article should be helpful to new researchers who are starting a study on the plant A. ferrox and will serve as a beneficial tool for them.

Cynanchum callialatum, known as Swallowwort or Milkweed, is a perennial herbaceous plant from the Apocynaceae family, prevalent in tropical and subtropical regions of Asia, including India and China. Renowned for its medicinal properties, the plant has been utilized in traditional medicine for centuries. This review highlights its taxonomy, morphology, habitat, distribution, medicinal uses, and phytochemical composition. Cynanchum callialatum's rich phytochemical profile includes alkaloids, flavonoids, glycosides, saponins, tannins, and steroids, contributing to its wide range of therapeutic applications. Key medicinal uses encompass antimicrobial, anti-inflammatory, digestive, and respiratory benefits. The plant's wound healing properties, primarily attributed to tannins, promote skin regeneration and protect against microbial infections Antiinflammatory and antioxidant activities of Cynanchum callialatum have been confirmed by Shinde et al. (2019), showing significant reduction in inflammation and oxidative stress. Additionally, the cardioprotective effects of its glycosides, as explored in previous study, demonstrated improved heart function and protection against cardiovascular diseases. The comprehensive phytochemical analysis underscores the plant’s medicinal potential, supporting its integration into modern therapeutic practices and paving the way for future pharmacological research