Ormacarpum cochichinase is a shrub Which is extremely efficacious in mending bone fractures,but at present it's use is known
only to handful of villagers in the tropical dry evergreen forest areas of Tamil Nadu for healing bone fractures . Other than
bone mending this plant have some more pharmacological potentials like anti-inflammatory, anti-arthritic, muscitocidal, antimicrobial and so on. This study aims on phytochemical analysis and the study of anti-inflammatory potential. The
phytochemical analysis was done by various chemical tests and the anti-inflammatory potential was studied by using egg
albumin denaturation assay. Further research works should be carried out for the better understanding of this plant and it`s
pharmacological potential.
2.
PHARMACOLOGICAL STUDIES ON LAVANDULA STOECHAS IN
HEPATOCELLULAR CARCINOMA
Cancer is one of the most complicated diseases with various treatments, which each has its special side effects.
So, pharmaceutical companies are intended to develop new drugs with minimum side effects. Objectives: The current study
aimed to investigate the cytotoxicity effects and the redox potential of alcoholic extract of Lavandula Stoechas leaf on liver
carcinoma cell line (HepG2). Methods: Lavandula Stoechas leaves were collected from Bhopal (India), and the alcoholic
extract of the plant leaves was prepared. HepG2 cells were cultured in DMEM medium and treated with 50, 100, 200, 400, and
600 µg/mL of the extract. The cytotoxicity effect of the extract was evaluated using the MTT and the Neutral Red assays.
Redox potential in HepG2 cells was assessed using NO, catalase, and GSH tests. The expression of Bax and bcl-2 genes in
HepG2 cells was evaluated for apoptosis analysis. Results: The results showed that the extract could significantly (P < 0.001)
reduce the viability of HepG2 cells. Also, the extract significantly increased the amount of released NO, catalase activity, and
GSH concentration. RT-PCR results showed that Lavandula Stoechas leaf extract significantly change the expression of bax
and bcl-2. Conclusions: The results showed that the leaves of the Lavandula Stoechas plant contain compounds with
cytotoxicity properties, so it can be considered as a potent candidate for liver cancer treatment