Introduction: Historically, Ayurvedic medicine has grouped plant compounds into categories according to their effects (for example, healing, promoting vitality, or relieving pain). Modern pharmacy now deals with medicinal plants and getting excellent biological activity of those plants. Papaya leaf extract is derived from the leaves of papaya tree. Papaya tree is commonly found everywhere in India. Papaya tree can said medicinal plant as it has proven several biological activity and active against several diseases. There are many health benefits of papaya leaf extract has found including micronutrient provider, red blood cell production, immune booster, antibacterial activity, antioxidant activity and aids in digestion. This study is focusing on the antibacterial and antioxidant properties of papaya leaf extract. These factors have inspired the widespread screening of plants for possible medicinal, antimicrobial and antioxidant properties. Dengue fever commencing on studies of the research on 70 dengue fever patients, said papaya leaf juice helps increase white blood cells and platelets, normalizes clotting, and repairs the liver. Aim of the work: To perform the preliminary phyto chemical screening and review to know its biological activity on Caricca Papaya leaves. Conclusion: They produce definite physiological action on the human body. In this study carcica papaya was selected for qualitative phyto chemical screening and for reporting biological activities. The extracts green leaves of Carica papaya are rich in phytochemicals coupled with the presence of Flavonoids, Carbohydrates, Steroids and Alkaloids. Carica papaya leaves can be used as a potential source of food and in drug items. The analytical techniques like Gas chromatography and Mass spectroscopy were performed and the compounds were found.
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HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF BARLERIA GIBSONII AGAINST THIOACETAMIDE INDUCED HEPATOTOXICITY IN RATS
The aim of the study is to investigate the hepatoprotective activity of ethanolic extract of leaves of Barleria gibsonii
against thioacetamide induced hepatotoxicity. The phytochemical screening was carried on the leaves extracts of Barleria
gibsonii revealed the presence of some active ingredients such as Carbohydrates, Tannins, Saponines, Phenols, steroids,
terpenoids and flavonoids. Leaves of Barleria gibsonii was successively extracted with ethanol and it is treated
against Thioacetamide (100 mg / kg s.c) induced hepatotoxicity using Standard drug Silymarin (100mg/kg). There was a
significant changes in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum
glutamate oxaloacetate transaminase (SGOT), Serum alanine phosphatase (SALP), serum bilirubin, Cholesterol and
triglyceride levels and reduces the total proteins and albumin content) in thioacetamide treated rats, which were restored
towards normalization in Barleria gibsonii (250 mg/kg, 400 mg /kg and 500 mg/kg) treated animals. Thus the present
study ascertains that the ethanolic leaf extract of Barleria gibsonii possesses significant hepatoprotective activity
3.
SIMULTANEOUS ESTIMATION OF CURCUMIN AND PIPERINE IN MARKETED FORMULATION
Turmeric contains a yellow-colored chemical called curcumin, which is often used to color foods and cosmetics. Turmeric is commonly used for conditions involving pain and inflammation, such as osteoarthritis. It is also used for hay fever, depression, high cholesterol, a type of liver disease, and itching. Piperine has been shown to help relieve nausea, headaches and poor digestion and also has anti-inflammatory properties. This explains how piperine can help to make curcumin more bioavailable. With just 1/20 teaspoon or more of black pepper, the bioavailability of turmeric is greatly improved, and turmeric's benefits are further enhanced. The developed UV-Visible Spectrophotometric method for the simultaneous estimation of curcumin and piperine in the tablet dosage form in the solvent system methanol and distilled water 1:1 ratio give proper estimation of percentage label claim of marketed product.