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The study investigates the antioxidant and antidepressant potential of the ethanolic extract of Yucca elephantipes (YEEE).
Preliminary phytochemical screening revealed the presence of various bioactive compounds such as carbohydrates, proteins,
amino acids, lipids, tannins, saponins, steroids, flavonoids, alkaloids, terpenoids, glycosides, and fats and oils. The antioxidant
activity of YEEE was evaluated using DPPH, hydrogen peroxide, and nitric oxide scavenging assays. The results demonstrated
significant free radical scavenging abilities, with a concentration-dependent increase in activity. In vivo antidepressant activity
was assessed using the open field test, forced swim test, and tail suspension test on Swiss Albino mice. YEEE showed a
significant reduction in immobility time and increased locomotor activity at both 200 mg/kg and 400 mg/kg doses compared to
the control group. The extract's efficacy was comparable to the standard antidepressant, Imipramine, indicating its potential as
a natural therapeutic agent for oxidative stress-related conditions and depression. These findings suggest that YEEE possesses
strong antioxidant properties and significant antidepressant-like effects, warranting further research to isolate specific bioactive
compounds and explore their mechanisms of action
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